Abstract: Nonsense mutations in the DMD gene account for approximately 15% mutations in patients with dystrophinopathy and usually result in the Duchenne muscular dystorophy (DMD) phenotype. However, less than 5% of the Becker muscular dystrophy (BMD) patients are known to carry nonsense mutations.
The findings that the retinoblastoma tumor suppressor gene product (pRB) controls gene expression by physically interacting with several epigenetic regulators reveals another potential form of the RB functions in global regulation of the epigenome beyond its well known functions in regulation of the E2F and tissue specific transcription factors. This plethora of novel RB functions may explain why RB should be inactivated in the vast majority of human cancers, and will provide insights for better understanding the future rationale for the epigenetic therapy of cancers.
Abstract: The ability of the brain to reorganize connections functionally and structurally in response to experience is termed "plasticity". Non-invasive transcranial electrical or magnetic stimulation have been demonstrated to modulate neurons' activity in human brain.
Abstract: Functional MRI (fMRI) basic cognitive paradigms such as the n-back have been shown to detect cognitive impairment (CI) in Multiple Sclerosis (MS). The immediate memory task/delayed memory task (IMT/DMT) detects varying degrees of working memory (WM) by alternating three levels of complexity and two levels of WM delay. This paradigm has not been evaluated in MS nor validated against standard neuropsychological (NP) testing.
Abstract: Principles and applications of dielectrophoresis (DEP) of biomolecules, suspended in aqueous medium, are reviewed. Biomolecules include nucleic acids (DNA and RNA), proteins, carbohydrates and lipids, and vary significantly in their composition and their behavior in aqueous medium. Review of dielectric polarisability principles and DEP fundamentals, therefore, focuses on two important biomolecules of interest in today's laboratory: double stranded DNA and ideal biocolloids (nanospheres).
Abstract: Natural compounds have been discovered to be effective in many disease treatments. Among these compounds are epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG), two abundant polyphenolic catechins in green tea. They have been found to be able to interfere with many disease-related biochemical processes in vitro. They are capable of suppressing inflammation, tumor growth, bacterial infection, and virus infection.
Abstract: Preeclampsia is characterized as new onset maternal hypertension and proteinuria after 20 weeks gestation. Studies suggest that endothelin (ET-1) is a regulator of vascular function in preeclampsia and plays a major role in mediating chronic reduction in uterine perfusion pressure (RUPP)-induced hypertension. We recently demonstrated a role for the autoimmune cytokine interleukin 17 (IL-17) in causing placental oxidative stress and hypertension during pregnancy. In this current study...
Abstract: Since the initial description of the human SLC23A1 transcript, encoding a sodiumdependent ascorbic acid transporter, no alternative splice variant had been described. In this report we describe a novel human specific alternative first exon which is located 1078 nucleotides 5' of the canonical first exon.
Abstract: The purpose of this study in vitro was evaluate the degree of conversion (DC%), sorption (Sp) and solubility (Sl) of a methacrylate composite (Filtek™ Z250) and silorane-based composite (Filtek™ P90)...
Abstract: There is a general consensus that soil organic carbon (SOC) stabilization and destabilization processes are mainly controlled by three major mechanisms: recalcitrance of C inputs, physical protection and chemical protection. However, integration of these mechanistic processes for accurate simulation of SOC-climate feedbacks is still in infancy, partly due to the lack of process-level experimental data. We conducted 8 hour sorption experiments and 1 year decomposition experiments in order to understand the linkages between sorptive chemical protection and C stabilization.
Authors: Joseph Tarsia1, Tiffany R. Chang1,2, Aimee Aysenne1, Amelia K Boehme3, Alton E. Sartor1, Karen C. Albright3-5, Ethan Arda Yalvac6, Rebecca Kruse-Jarres7, Cindy Leissinger7 and Sheryl Martin-Schild1*